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What is the world-renowned Dr.Jóia PRPF therapy? 

Why is PRPF Therapy Reliable?
~15 years of history and achievements

The PRPF Therapy Research Group holds a workshop every year (hosted by Ms. Tomoko Hayashi, Chairperson / location: Jóia Clinic Kyoto).

PRP is platelet rich plasma, which is a concentration of one's own platelets. It is known that adding a high-performance growth factor called b-FGF to this PRP can greatly increase its effectiveness. On the other hand, there are concerns about the safety of b-FGF, and some people say that it can cause lumps. (See: Is the popular PRP injection method really good?)

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Our original PRPF therapy is a safe and highly effective state-of-the-art regenerative medicine that accumulated academic evidence through joint research, visiting the Institute for Former Institute for Frontier Medical Sciences for Regenerative Medicine and Public Institutions by the director herself from 13 years ago.

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　In fact, I think there are many people who do not know the details when you hear PRP therapy. Director's original, Dr. Jóia formula PRPF therapy and the differences will also be explained in detail.

Dr. Jóia's PRPF therapy is recommended for the following patients

　　Dark circles and sagging under the eyes

　　Want more volume on my temples and forehead.

　　Want to improve the appearance of my cheeks and gorgon line.

　　Want to remove fine lines and wrinkles on my neck.

　　Want to reduce fine lines and wrinkles on my neck.

　　Want to improve the appearance of fine lines and wrinkles on my cheeks and jawline.

　　Want to improve my atopic skin (skin texture improvement)

　　Want to improve atopic skin (skin texture improvement) ・Want natural-looking results

　　Want long-term results (lasts for about 4 years).

　Dr. Jóia's PRPF is a recommended treatment for those who are considering hyaluronic acid or fat injections (see comparison article link).

 

The delicate injections can improve thin skin and subtle shadows around the eyes, neck wrinkles, and other areas where hyaluronic acid or fat injections would result in an uneven appearance.

PRP therapy is recommended for these people

Concerned about thinning hair
　　Want to improve fine lines and wrinkles
　　Dullness of the skin
　　Want to improve the elasticity of my skin.
　　Want to take anti-aging to the next level

PRP by itself is effective, but its effects can be further enhanced in collaboration with collagen and stem cell-based ingredients. Our clinic introduced the MP-gun (meso-gun) injection machine last year, which is the most advanced meso-gun that can be injected into the dermis without pain.

(There is no leakage like with hydrophotonic injections.)
It is suitable for those who wish to "regenerate aged skin itself" or "regenerate hardened scalp.

What is PRP (platelet-rich plasma)?

PRP therapy (platelet-rich plasma therapy) is, as the name suggests, regenerative medicine that injects plasma components containing a large number of platelets extracted from blood.

 

By utilizing the natural healing power of platelets and promoting tissue repair, it is used for "skin regeneration" such as fine lines and wrinkles and skin texture improvement, and overseas, especially for "scalp regeneration" such as hair growth and hair regrowth.

 

In the field of orthopedics, it is also used for elbow and knee pain and for the regeneration of cartilage and ligaments. Because it uses autologous blood, it has become popular in recent years as a relatively safe therapy.

What is Dr. Jóia's PRPF Therapy?

Our original Dr. Jóia style PRPF therapy sounds like an application of PRP therapy, but in fact its use is completely different.
The effect of PRP alone is actually very mild and can rejuvenate the skin itself, but it is impossible to produce volume.

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PRPF, when injected subcutaneously, can regenerate adipose tissue after one month and can regenerate almost equal amounts of fat to the amount injected.

 

In other words, like hyaluronic acid and fat injections, PRPF can regenerate the desired amount of autologous fat in the desired area, and since the regenerated fat is not absorbed, semi-permanent volume enhancement is now possible.

What is Dr. Jóia's PRPF Therapy?

Our original Dr. Jóia style PRPF therapy sounds like an application of PRP therapy, but in fact its use is completely different.
The effect of PRP alone is actually very mild and can rejuvenate the skin itself, but it is impossible to produce volume.

​

PRPF, when injected subcutaneously, can regenerate adipose tissue after one month and can regenerate almost equal amounts of fat to the amount injected.

 

In other words, like hyaluronic acid and fat injections, PRPF can regenerate the desired amount of autologous fat in the desired area, and since the regenerated fat is not absorbed, semi-permanent volume enhancement is now possible.

Treatment using b-FGF (basic fibroblast growth factor) is known to be highly effective in treating skin ulcers. However, b-FGF, a growth factor, is like a supercar with an order of magnitude different performance, and it is a difficult cytokine that can cause trouble if used in the wrong way. In the aesthetic field, many troubles such as lump formation and persistent redness have been reported.

 

　The Director began joint research at the Institute for Former Institute for Frontier Medical Sciences for Regenerative Medicine and Public Institutions 13 years ago, and finally established a physiological protocol that combines the synergistic effects of PRP and b-FGF with safety. The research proved that PRP and b-FGF injected subcutaneously at a certain concentration can regenerate adipose tissue after one month. Moreover, when the protocol is adjusted to the optimum concentration, almost the same amount of fat can be regenerated as the injected amount. In other words, the desired amount of autologous fat can be regenerated in the desired area, and since the regenerated fat is not absorbed, semi-permanent volume enhancement is now possible.

 

Moreover, since the fat is liquid when injected, it can be injected into delicate areas with a very fine needle. This regenerative medicine is overwhelmingly superior to fat injection and hyaluronic acid, and named PRPF therapy.

 

　PRPF therapy was started in 2010 with the director's original protocol, which was born from a deep understanding of regenerative medicine and advanced injection techniques, and has accumulated several hundred cases, there have been no major problems or aftereffects. It is now one of our most popular treatments and has received international acclaim.

 

　*All treatments using PRP are included in Type 3 of the "Law Concerning Safety Assurance of Regenerative Medicine, etc." enacted in 2014, and clinics handling PRP are required to notify the Ministry of Health, Labour and Welfare of such treatment. Our clinic is the fourth in the Kinki area (the first in cosmetic medicine) to officially obtain a facility/manufacturing number.

Why Dr. Jóia's PRPF Therapy is Safe

Simply adding b-FGF (fibroblast growth factor: one of the growth factors) to PRP does not mean that it is PRPF therapy.

Reasons for safety #1: Calcium chloride is not used.

Calcium chloride is often added to activate platelets, but there is a risk of inflammation and lump formation when injected subcutaneously.
It is a dangerous ingredient that the product's package insert warns may cause induration and necrosis if it enters the extravascular space.
Calcium chloride is not used in PRPF therapy.

Reason for safety #2: Adequate intervals between treatments.

PRPF therapy is a regenerative medicine that makes physiological use of the immune response to heal wounds (i.e., wound healing mechanism) that the human body is equipped with to regenerate tissues.

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The body has a tendency to remember injuries and stress. If the same place is repeatedly hit, a bump will form, and if the same place is repeatedly injured, it will be difficult to heal and will become raised.

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Injecting PRPF repeatedly into the same area every few months may cause an overreaction, so as a general rule, PRPF therapy to the same area should be given after a one-year interval.

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We believe that it is a very important point for regenerative medicine to be performed after the body's memory has sufficiently faded.

Reason For safety #3: Do not perform on areas where foreign matter is present.

PRPF therapy is regenerative medicine that makes physiological use of the immune reaction (= wound healing mechanism) to heal wounds that are present in the human body and regenerate tissues.


Thread lift threads, silicon prosthesis, etc., which do not exist in the human body, are called foreign bodies, but the immune response may attack them, so PRPF is not injected into the surrounding area where there are foreign bodies.

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PRPF is also not injected into areas where fat has already been injected, because PRPF regenerates tissue by acting on the cells of the tissue surrounding the injection site. This is because the injected fat still has the properties of the original location (the same properties as the fat in the donor's abdomen or inner thighs), so there is a high possibility that it will look unnatural if fat with different properties than the fat in the face is increased.

Reason for safety #4: PRP is used without white blood cells.

Many facilities include a high white blood cell content when purifying PRP, but white blood cells produce inflammatory cytokines that can cause redness and burning after treatment. They can also cause allergies after treatment.

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In the past, some facilities used a method called W-PRP, in which a large number of white blood cells are intentionally injected into the skin, but this has caused many dangerous problems (and some facilities may still do this).

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PRPF therapy uses PRP that does not contain white blood cells, so there is no risk of redness or allergic symptoms.

Reason for safety #5: Appropriate amount of b-FGF is added.  

Since b-FGF (fibroblast growth factor) is a superstar cytokine, the amount of its addition is very important. Based on the results of joint research with Former Institute for Frontier Medical Sciences for Regenerative Medicine and Public Institutions, the director himself determined that 10 μg of b-FGF per 1 cc of PRP is the appropriate amount.

He also succeeded in determining that a concentration of 1 to 2 million per microliter of PRP is the most effective. In other words, the physiological amount of PRP added is as close as possible to the concentration required for the immune response of wound healing in the human body.
Only PRPF therapy has such a precise protocol for the concentration of PRP and b-FGF.
 

Reason for safety #6: Experienced doctors with a thorough understanding of the three-dimensional anatomy of the face perform the surgery.

PRPF therapy, which is regenerative medicine rather than mere injectables, lasts an average of more than four years after a single treatment. Under the eyes, the effect lasts almost semi-permanently. 

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We believe that this treatment is possible only because we are cosmetic surgeons who have performed many cosmetic surgical procedures such as facelifts and lower eyelid Hamra procedures and are familiar with the three-dimensional anatomy of the face.

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Because the effect of just one treatment is surprisingly high, the PRPF Therapy Research Group selects and instructs doctors with sense and morals.

Reason for safety #7: Always follow up all cases within one month.

If the amount injected is too much or the volume is not as desired, there is no need to worry, as the volume can be reduced with steroid injections within a month (although almost never if done under a good doctor). As a general rule, we always follow up all patients at the second week.

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